The aim of the present study was to examine the effect of injected MA (5 mg/kg) on maternal behavior of rats and the differences in postnatal development, during postnatal days (PD) 1–11, of pups when the pups were directly exposed (i.e., injected) to MA or received MA indirectly via breast milk. Since it enters breast milk, methamphetamine (MA) abuse during lactation can not only affect the quality of maternal behavior but also postnatal development of pups. The current findings suggest that in addition to the immediate effects on body weight, amphetamine may alter the rate of growth, and increase the risk for weight-related adult diseases. Moreover, the lack of effect on brain weight shows that AMPH differentially affects somatic and brain growth. These findings support the idea that developmental AMPH exposure transiently restricts somatic growth. Further, no differences in brain weight were observed at either age as a result of AMPH exposure. However, this was transient in nature, with no significant difference in weight observed after pups were weaned on PD21. Weights of these brain regions from young adult rats were also assessed on PD68.ĪMPH exposure during early postnatal development limited somatic growth in a dose-related manner, with significantly lower body weights in animals assigned to the AMPH 25 and AMPH 15 groups. On PD9, a subset of animals was terminated 90min after the last amphetamine treatment and the weights of the cortex, cerebellum, and brainstem were collected. Body weight data were collected every other day from PD1 to 21, and then weekly until PD59. Rats received 0, 5, 15 or 25mg/kg/day of AMPH via two daily intragastric intubations from PD4-9. Here, the effects of d-amphetamine sulfate (AMPH) exposure during the brain growth spurt period on this potential indicator were evaluated.
#DEVELOPER AMPHETAMINE UPDATE#
I wasn't in the middle of trying to update Amphetamine or anything.Restricted somatic growth during fetal or early postnatal periods has been suggested to serve as a predictive indicator for neuroanatomical changes and behavioral impairments during adulthood. "I found it odd that this issue came up out of nowhere.
"I specifically asked Apple on the phone if this was a result of customer complaints and Apple's response was 'I don't think so,'" he said. Gustafson told The Verge he got a call Saturday from Apple granting his appeal- but he didn't have insight into how the app was flagged in the first place. The logo features a cartoon image of a pill. Gustafson said in January 1st posts on Reddit and Github that Apple had informed him he had two weeks to "remove all references to the word 'amphetamine' and remove the pill from the icon." If he failed to do so, Gustafson wrote, Apple said it would remove the app from the App Store on January 12th.
Not long after The Verge reached out to Apple for comment on Saturday however, the company reversed its decision, and the app will be able to stay up with its current name and logo. The developer of Amphetamine, an app that prevents Macs from going into sleep mode, says Apple told him it violated App Store guidelines, even though it's been in the App Store since 2014, and has nothing to do with drug use.
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